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KMID : 0928320080080020117
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Korean Journal of Health Promotion and Disease Prevention
2008 Volume.8 No. 2 p.117 ~ p.122
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Effects of Environmental Facters on RUX3 Promoter Hypermethylation in Gastric Cancer Tissue
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Eom Sang-Yong
Youn Sei-Jin
Kang Jong-Won
Kim Heon
Zhang Yan-Wei
Kim Yong-Dae
Yun Hyo-Yung
Song Young-Jin
Park Joo-Seung
Hyun Tai-Sun
Woo Byung-Wan
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Abstract
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Background: This study aimed to investigate the effects of environmental factors on hypermethylation of the RUNX3 gene promoter gastric cancer tissues in Korea.
Method: 142 gastric cancer patients were enrolled. Exposure data to environmental factors were collected by interview.
Hypermethylation of the RUNX3 gene promoters were analyzed in gastric cancer tissue.
Results:Kimchi, soybean foods, stews, jam, honey, candies, chocolate and vitamin B6 intake increased the risk of hypermethylation
of the RUNX3 gene promoter.
Conclusions: Some dietary factors may be related with hypermethylation of the RUNX3 gene promoter in gastric cancer tissue.
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KEYWORD
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Gastris cancer, Diet, RUNX3, Hypermethylation
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